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IBS / Colitis / Coeliac disease - Chronic diarrhoea & abdominal pain

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Irritable bowel syndrome (IBS)

This is a very common syndrome with symptoms that are very similar to several other conditions;

firstly colitis, which is often referred to as inflammatory bowel disease and includes 2 main conidtions (ulcerative colitis and Crohn's disease),

secondly coeliac disease also known as gluten-sensitive enteropathy, and

thirdly infections including food poisoning although the diarrhoea is generally more acute if there is an infection.

As the symptoms of these conditions are similar tests are often required to tell the difference. Some people complain that it is not always easy to get access to the appropriate tests and we offer several simple tests that can help. If the symptoms, in particular the diarrhoea is acute then an infection should be considered and a sample of stool cultured to see if any disease-causing bacterial organisms are present. Buy this stool culture test for acute diarrhoea.

If the condition is longstanding (chronic) then stool culture is not usually necessary. Most useful is a test of the degree of inflammation of the bowel wall. In colitis, an inflammation of the bowel, there is much inflammation and the Calprotectin level is high. In IBS there is little or no inflammation and the Calprotectin level is low or normal. We can measure the Calprotectin level in a sample of stool that you send to us. Buy the Calprotectin test to find out if you are more likely to have colitis or irritable bowel syndrome.

Finally, it is increasingly recognised that adults can suffer from gluten-sensitive enteropathy a condition formerly diagnosed mainly in children. Adults can be allergic to wheat and suffer chronic diarrhoea as a result but not recognise this for years. A simple blood test that you perform at home can tell if you are at risk of Coeliac disease. Buy this Coeliac test if you have symptoms of irritable bowel syndrome.

Other causes of diarrhoea and lower abdominal pain

Of course, there are very many other causes of diarrhoea and it is important that any new or severe symptoms are reported to your GP without delay to exclude serious disease such as appendicitis, pancreatitis, diverticulitis etc.

Important: drugs can affect the Calprotectin test result

If you are taking 'non-steroidal anti-inflammatory drugs' such as Ibuprofen or Aspirin then the Calprotectin level can be raised as these drugs cause intestinal inflammation. Studies on people taking low dose aspirin for prevention of strokes and heart disease however did not show raised Calprotectin levels. If in doubt about your medication consult the list below or phone us for advice before ordering the test.

Instructions for collecting the stool sample

1. Collect a sample of stool into a clean dry plastic container

2. Unscrew the cap of the sample collection device (take care as there is fluid in the tube that must be retained) and push the stick 2cm into the faeces

3. Pull the stick out and insert it into the collection device. Screw cap on firmly then shake well.

4. Repeat steps 2 and 3 until you have taken 2 samples.

 

Details about the Calprotectin test for IBS / colitis

The detection of Calprotectin in faeces allows colitis to be separated from the irritable bowel syndrome (IBS). Calprotectin is a substance present in inflammatory cells (neutrophil polymorphs and monocytes) also known as the white cells of the blood that fight against infection. This substance is very stable so can be measured up to one week after a stool sample has been taken. It is a reliable marker of colitis (inflammatory bowel disease) and there are many scientific papers that document its value (see below). It can be used in conjunction with the FOB test for blood in stool for detecting bowel cancer as Calprotectin is often also increased when there are polyps or a cancer.

The Calprotectin test result gives 4 possible results:

Negative (Calprotectin not detectable) or

Low (Calprotectin less than 15 microg /g)

Interpretation No bowel inflammation present

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Medium (Calprotectin 15-60 microg /g)

Interpretation Bowel inflammation is present

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High (Calprotectin greater than 60 microg/g)

Interpretation A highly active inflammatory process is present in the bowel

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Invalid test (No result)

Interpretation The test must be repeated

 

Sampler

 
   

Oxford Screening